A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA
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- 作者：Vipin Babua ; b ; Bjö ; rn Schumachera ; b ; bjoern.schumacher@uni-koeln.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：bp ; base pairs ; 6-4 PP ; 6-4 photoproduct ; cm ; centimeter ; CPD ; cyclobutane pyrimidine dimer ; CS ; Cockayne syndrome ; GG-NER ; global-genome nucleotide excision repair ; mJ ; milli-joule ; NER ; nucleotide excision repair ; NGM ; nematode growth medium ; nt ; nucleotide ; ORF ; open reading frame ; RNAP II ; RNA polymerase II ; RRS ; recovery of RNA synthesis ; TC-NER ; transcription-coupled nucleotide excision repair ; UDS ; UV-induced DNA repair synthesis ; UTR ; un-translated region ; UV ; ultraviolet ; UVSS ; UV-hyper
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：8-15
- 全文大小：1091 K
文摘
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UV-stimulated scaffold protein A (UVSSA) gene, a causal gene of UV-hypersensitivity syndrome, has a C. elegans homolog—uvs-1.
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uvs-1 mutant animals are defective in repairing CPD lesions and are hypersensitive to UV during development.
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UV-B irradiation reduces the life span of uvs-1 animals.
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uvs-1 and csb-1 function epistatically to promote UV-resistance.
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uvs-1 mutant animals are hypersensitive to the transcription-blocking DNA lesions induced by illudin-M.