- 作者：Olivier Chapet ; MD ; PhD&lowast ; ; olivier.chapet@chu-lyon.fr ; Corina Udrescu ; MS&lowast ; ; &dagger ; ; Marian Devonec ; MD ; PhD&Dagger ; ; Ronan Tanguy ; MD&lowast ; ; Marie-Pierre Sotton ; MS&dagger ; ; Ciprian Enachescu ; MD&lowast ; ; Marc Colombel ; MD ; PhD§ ; ; David Azria ; MD ; PhD¡¬ ; Patrice Jalade ; PhD&dagger ; ; Alain Ruffion ; MD ; PhD&Dagger ;
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2013
- 出版时间：1 May, 2013
- 年：2013
- 卷：86
- 期：1
- 页码：72-76
- 全文大小：354 K
Purpose
The aim of this study was to evaluate the contribution of an injection of hyaluronic acid (HA) between the rectum and the prostate for reducing the dose to the rectal wall in a hypofractionated irradiation for prostate cancer.Methods and Materials
In a phase 2 study, 10 cc of HA was injected between the rectum and prostate. For 16 patients, the same intensity modulated radiation therapy plan (62 Gy in 20 fractions) was optimized on 2 computed tomography scans: CT1 (before injection) and CT2 (after injection). Rectal parameters were compared: dose to 2.5 cc (D2.5), 5 cc (D5), 10 cc (D10), 15 cc (D15), and 20 cc (D20) of rectal wall and volume of rectum covered by the 90 % isodose line (V90), 80 % (V80), 70 % (V70), 60 % (V60), and 50 % (V50).
Results
The mean V90, V80, V70, V60, and V50 values were reduced by 73.8 % (P<.0001), 55.7 % (P=.0003), 43.0 % (P=.007), 34 % (P=.002), and 25 % (P=.036), respectively. The average values of D2.5, D5, D10, D15, and D20 were reduced by 8.5 Gy (P<.0001), 12.3 Gy (P<.0001), 8.4 Gy (P=.005), 3.7 Gy (P=.026), and 1.2 Gy (P=.25), respectively.
Conclusions
The injection of HA significantly limited radiation doses to the rectal wall.