Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine
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- 作者：Florian Duclota ; b ; 1 ; Iara Perez-Taboadaa ; b ; 1 ; 2 ; Katherine N. Wrighta ; b ; Mohamed Kabbaja ; b ; mohamed.kabbaj@med.fsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fear conditioning ; Novelty seeking ; Individual differences ; Fear extinction ; Ketamine ; Fear memory reconsolidation
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：293-305
- 全文大小：1708 K
文摘
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Individual differences in novelty seeking in rats predict rate of fear extinction.
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High novelty seeking rats show faster fear extinction than low novelty seeking rats.
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Ketamine impairs reconsolidation of contextual fear memory.
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Ketamine’s effects are associated with early growth response 1 down-regulation in CA1.
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