Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice
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- 作者：Sebastian Brachs1 ; 2 ; Sebastian.Brachs@charite.de" class="auth_mail" title="E-mail the corresponding author ; Angelika F. Winkel3 ; Angelika.Winkel@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Hui Tang1 ; 2 ; Hui.Tang@charite.de" class="auth_mail" title="E-mail the corresponding author ; Andreas L. Birkenfeld1 ; 2 ; 4 ; Andreas.Birkenfeld@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Bodo Brunner3 ; Bodo.Brunner@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Kerstin Jahn-Hofmann3 ; Kerstin.Jahn-Hofmann@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Daniel Margerie3 ; Daniel.Margerie@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Hartmut Ruetten3 ; Hartmut.Ruetten@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Dieter Schmoll3 ; Dieter.Schmoll@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Joachim Spranger1 ; 2 ; joachim.spranger@charite.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：INDY/Slc13a5 ; siRNA ; Insulin resistance ; Steatosis ; Citrate transport ; Lipid accumulation
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：5
- 期：11
- 页码：1072-1082
- 全文大小：1782 K
文摘
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mINDY/Slc13a5 knockdown was induced by liver-selective siRNA in mice.
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Liver-selective knockdown of mINDY improved hepatic insulin sensitivity.
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Liver-selective knockdown of mINDY prevented steatosis hepatis.