Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway
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- 作者：Lei Hu1 ; Ming-de Zang1 ; He-xiao Wang1 ; Jian-fang Li ; Li-ping Su ; Min Yan ; Chen Li ; Qiu-meng Yang ; Bing-ya Liu ; liubingya@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zheng-gang Zhu ; zzg1954@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BGN ; Endothelial cells ; TLR2/4 ; VEGF ; Angiogenesis ; GC
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：10
- 期：9
- 页码：1473-1484
- 全文大小：3258 K
文摘
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BGN is member of SLRPs, which is found in a variety of human cancers.
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BGN stimulation of endothelial cells increased the expression of VEGF through NF-kB and the HIF-1α.
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BGN enhanced endothelial cell migration, proliferation and tube formation in a TLR signaling pathway-dependent manner.
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Endothelial cell-derived VEGF in turn acts on GC cells and promotes the migration of GC cells.