Barbier-type reaction mediated with tin nano-particles in water

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• 作者：Zha ; Zhenggen ; Qiao ; Shu ; Jiang ; Jiaoyang ; Wang ; Yusong ; Miao ; Qian ; Wang ; Zhiyong
• 关键词：Tin ; Nano-particles ; Barbier-type reaction ; Mechanism ; Water
• 刊名：Tetrahedron
• 出版年：2005
• 出版时间：February 28, 2005
• 年：2005
• 卷：61
• 期：9
• 页码：2521-2527
• 全文大小：197 K

文摘

Tin nano-particles are employed in the Barbier-type allylation reaction of carbonyl compounds in water to afford the corresponding homoallylic alcohols in good yields. The in situ generated allylation intermediates, allyltin(II) bromide and diallyltin dibromide, have been directly observed by using ¹H NMR. A mechanism is proposed based on this observation.