Stochasticity and bifurcations in a reduced model with interlinked positive and negative feedback loops of CREB1 and CREB2 stimulated by 5-HT
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- 作者：Lijie Haoa ; Zhuoqin Yang ; a ; yangzhuoqin@buaa.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuanhong Bia ; b
- 关键词：Long-term memory ; Feedback loop ; Bifurcation ; Stochasticity
- 刊名：Mathematical Biosciences
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：274
- 期：Complete
- 页码：73-82
- 全文大小：3927 K
文摘
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A reduced model for creb gene expression stimulated by 5-HT is developed.
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Changing [5-HT] and positive strength can generate different dynamics.
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The deterministic bifurcation diagrams can predict stochastic behaviors.