Estrogen receptor-regulated microRNAs contribute to the BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions

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• 作者：Rong  ; Zhang^a ;   ; ¹ ;   ; ^{rongzhang@163.com} ; Yifeng  ; He^b ;   ; ¹ ;   ; ^{he_yifeng@hotmail.com} ; Xueli  ; Zhang^c ; Baolin  ; Xing^d ; Youhua  ; Sheng^e ; Huan  ; Lu^a ; Zhenhong  ; Wei^a
• 关键词：Estrogen receptor ; MicroRNA ; BCL2 ; BAX ; Type I endometrial carcinoma
• 刊名：Cancer Letters
• 出版年：2012
• 出版时间：28 January 2012
• 年：2012
• 卷：314
• 期：2
• 页码：155-165
• 全文大小：832 K

文摘

Uncontrolled estrogen exposure can induce an imbalance in BCL2/BAX expression in endometrial cells, leading to precancerous lesions and type I endometrial adenocarcinoma. This study aimed to explore the mechanism underlying this phenomenon. We show that the activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells. These ER-regulated hsa-let-7 microRNAs can be detected in most hyperplastic endometria, suggesting their potential utility as indicators of estrogen over-exposure.