Structure-based optimization of salt-bridge network across the complex interface of PTPN4 PDZ domain with its peptide ligands in neuroglioma

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• 作者：Xian Xiao^a ; ¹ ; Qiang-Hua He^a ; ¹ ; Li-Yan Yu^b ; ¹ ; Song-Qing Wang^a ; Yang Li^a ; Hua Yang^a ; Ai-Hua Zhang^a ; Xiao-Hong Ma^a ; Yu-Jie Peng^a ; Bing Chen^c ; ^{xiaox79@126.com}
• 关键词：PTPN4 PDZ domain ; Peptide ligand ; Salt bridge ; Neuroglioma
• 刊名：Computational Biology and Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：63-68
• 全文大小：1056 K
• 卷排序：66

文摘

The structural dynamics of peptide binding to PTPN4 PDZ domains is investigated systematically. A number of charged residues involved in a salt-bridging network is found across the binding interface. Potent peptide binders of the domain are designed by optimizing the salt-bridging network.