Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors

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• 作者：Gang Wang ; Yutao Wang ; Lei Wang ; Leiqiang Han ; Xuben Hou ; Huansheng Fu ; Hao Fang ; ^{haofangcn@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bcl-2 ; Imidazolidine-2 ; 4-dione ; Inhibitors ; Antitumor
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2015
• 出版时间：1 December 2015
• 年：2015
• 卷：23
• 期：23
• 页码：7359-7365
• 全文大小：656 K

文摘

Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276.