Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution
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- 作者：Qiaoqing Xua ; b ; Ronggai Lia ; Milena M. Montea ; Yousheng Jianga ; c ; Pin Nied ; Jason W. Hollanda ; Chris J. Secombesa ; c.secombes@abdn.ac.uk" class="auth_mail ; Tiehui Wanga ; t.h.wang@abdn.ac.uk" class="auth_mail
- 关键词：Rainbow trout ; CXCR2 ; CXCR3a ; CXCR3b ; Evolution ; Expression
- 刊名：Developmental and Comparative Immunology
- 出版年：August 2014
- 年：2014
- 卷：45
- 期：2
- 页码：201-213
- 全文大小：1902 K
文摘
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The cDNA sequences of CXCR2, CXCR3a and CXCR3b have been cloned in rainbow trout.
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The linked CXCR1/CXCR2 and CXCR3a/CXCR3b loci are hypothesised to have been present in the teleostomian ancestor.
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CXCR1 and CXCR2 have likely undergone gene conversion whilst CXCR3b has been lost in mammals.
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Compared with mammals, ray-finned fish possess more CXCR1–R3 receptors, but fewer ligands.
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Trout CXCR1–R3 are expressed in macrophages and neutrophils, with CXCR1/R2 also abundant in B-cells.