Do the distinct synaptic properties of VGLUTs shape pain?
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- 作者：Rebecca P. Seala ; b ; c ; rpseal@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vesicular glutamate transporter ; Pain ; Distribution ; Synaptic transmission ; VGLUT3 ; Neural circuits
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：82-88
- 全文大小：1114 K
文摘
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The three VGLUT isoforms have largely distinct expression patterns and synaptic properties in the adult nervous system.
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Vesicular glutamate transporters (VGLUTs) are essential for pain transmission throughout the nervous system.
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20">The distinct synaptic properties of VGLUTs affect synaptic transmission and likely also pain signaling.
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25">They dynamic regulation of VGLUTs also affects synaptic transmission and likely pain signaling.
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Understanding the dynamic nature of synaptic transmission within pain circuits may provide new strategies to treat pain.
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