Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia—Induced vascular dementia of rats
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- 作者：Yanjing Caoa ; Zengmei Gouc ; Yifeng Dub ; duyifeng2014@163.com" class="auth_mail" title="E-mail the corresponding author ; Yongjun Fand ; Lizhen Lianga ; Yongxing Yana ; Ping Lina ; Mudan Jina ; Yifenf Dub
- 关键词：AD ; Alzheimer&rsquo ; s disease ; VaD ; vascular dementia ; CCI ; Chronic Cerebral Global Ischemia ; vGluT1 ; vesicular glutamate transporters type 1 ; vGluT2 ; vesicular glutamate transporters type 1 ; vGluT3 ; vesicular glutamate transporters type 3 ; vAChT ; vesicular acetylcholine transporters ; vGAT ; vesicular GABA transporters
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：620
- 期：Complete
- 页码：169-176
- 全文大小：5034 K
文摘
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Glutamate, central cholinergic, GABAergic deficiency plays a critical role in AD.
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vGluT1, vGluT3 and vAChT is more sensitive than vGluT2, vGAT in VD.
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At the same time, CA1, CA2, CA3 circuits play an important role in the social, emotional, and temporal n spatial aspects of memory.
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20">So, vGlut1, vGlut3 and vAChT may be the important synaptic nerve terminals in CCI-induced VD.
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