Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression
详细信息 查看全文
- 作者：Darkiane Fernandes Ferreiraa ; Jarlei Fiamoncinib ; Iryna Hirata Prista ; Suely Kubo Arigaa ; Heraldo Possolo de Souzaa ; Thais Martins de Limaa ; thais@emercli.fm.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAFLD ; non-alcoholic fatty liver disease ; TLR ; toll like receptor ; LDLrKO ; low density lipoprotein receptor knockout ; HFD ; high fat diet ; Apo ; apolipoprotein ; MTTP ; microsomal triglyceride transfer protein ; GPAT ; glycerol phosphate acyltransferase ; ACOX ; acyl-CoA oxidase ; CPT-1 ; carnitine palmitoyl transferase-1 ; MTP ; mitochondrial trifunctional protein ; PBE ; peroxisomal bifunctional enzyme ; Thiol ; 3-ketoacyl-CoA thiolase ; NASH ; non-alcoholic steatohepatitis ; FFA ; free fatty acid ; FIA ; flow inje
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：1851
- 期：10
- 页码：1353-1359
- 全文大小：675 K
文摘
- •
TLR4/LDLr KO mice presented lower triglyceride plasma levels after HFD ingestion.
- •
TLR4/LDLr KO triglyceride accumulation in liver was lower than LDLrKO mice.
- •
Acyl-carnitine plasma profile showed an increase in C0 and C2 in TLR4/LDLr KO group.
- •
10">TLR4 deficiency enhanced fatty acid oxidation by the liver.