MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma
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- 作者：Jia Liua ; b ; Yu Maob ; c ; d ; Dakai Zhanga ; b ; Shengnan Haoe ; Zicheng Zhangb ; d ; Zhenjiang Lib ; f ; Baosheng Lib ; d ; baoshli1963@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ESCC ; esophageal squamous cell carcinoma ; EAC ; esophageal adenocarcinoma ; LNM ; lymph node metastasis ; MMP ; matrix metalloproteinase ; TIMPs ; tissue inhibitor of metalloproteinases ; ECM ; extracellular matrix
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：373
- 期：1
- 页码：97-108
- 全文大小：4534 K
文摘
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The expression level of miR-143 and its correlation between clinical parameters was explored.
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STAT3 was demonstrated to be a direct target of miR-143.
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MiR-143 could repress cell cycle and EMT signaling pathway by targeting STAT3 resulting in suppressing ESCC cell proliferation, migration and invasion.
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