Neuroprotective effect of hypobaric hypoxic postconditioning is accompanied by dna protection and lipid peroxidation changes in rat hippocampus

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• 作者：Oleg Vetrovoy^a ; ^b ; ^{vov210292@yandex.ru} ; ^{vov210292@gmail.com} ; Ekaterina Tulkova^a ; Ksenia Sarieva^a ; ^b ; Elena Kotryahova^b ; Mikhail Zenko^a ; Elena Rybnikova^a
• 关键词：Severe hypobaric hypoxi a ; Mild hypobaric hypoxia postconditioning ; Hippocampus ; Lipid peroxidation ; DNA fragmentation ; Neuroprotection.
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：49-52
• 全文大小：687 K
• 卷排序：639

文摘

Severe hypoxia induces intensive DNA fragmentation in rat hippocampus. The hippocampal level of thiobarbituric acid reactive substances (TBARS) is decreased with time after severe hypoxia. Hypoxic postconditioning is protective against severe hypoxia-induced DNA fragmentation. Postconditioning normalizes the hippocampal level of TBARS and down-regulates the amount of Schiff bases.