High-flow nasal cannula oxygen therapy for acute exacerbation of interstitial pneumonia: A case series

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• 作者：Yukihiro Horio^a ; ^{h_5amm1218@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Takahisa Takihara^a ; ^{ttakihara@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kyoko Niimi^a ; ^{niimi_k1002@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Masamichi Komatsu^b ; ^{im_little_pea@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Masako Sato^a ; ^{satomasa@tokai-u.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Tanaka^a ; ^{jntnk723@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hiroto Takiguchi^a ; ^{takihiroto@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hiromi Tomomatsu^a ; ^{hiromiogur@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Katsuyoshi Tomomatsu^a ; ^{k.tomomatu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Naoki Hayama^a ; ^{hayama@is.icc.u-tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tsuyoshi Oguma^a ; ^{tyoguma@db4.so-net.ne.jp" class="auth_mail" title="E-mail the corresponding author} ; Takuya Aoki^a ; ^{aokitaku@is.icc.u-tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tetsuya Urano^a ; ^{urantets@is.icc.u-tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Atsushi Takagi^b ; ^{takagia@is.icc.u-tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Koichiro Asano^a ; ^{ko-asano@tokai-u.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AEIP ; acute exacerbation of interstitial pneumonia ; HFNC ; high-flow nasal cannula ; FIO2 ; fraction of inspired oxygen ; PaO2 ; partial pressure of oxygen in blood ; IPF ; idiopathic pulmonary fibrosis ; NPPV ; non-invasive positive pressure ventilation ; CT ; computed tomography
• 刊名：Respiratory Investigation
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：54
• 期：2
• 页码：125-129
• 全文大小：797 K

文摘

We report 3 cases (all men, age: 69–81 years) of acute exacerbation of interstitial pneumonia (AEIP) that were successfully treated with a high-flow nasal cannula (HFNC), which delivers heated, humidified gas at a fraction of inspired oxygen (FIO₂) up to 1.0 (100%). Oxygenation was insufficient under non-rebreathing face masks; however, the introduction of HFNC with an FIO₂ of 0.7–1.0 (flow rate: 40 L/min) improved oxygenation and was well-tolerated until the partial pressure of oxygen in blood/FIO₂ ratio increased (between 21 and 26 days). Thus, HFNC might be an effective and well-tolerated therapeutic addition to the management of AEIP.