Formononetin attenuates Aβ_25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP

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• 作者：Lizhi Chen ; Shanshan Ou ; Lingqi Zhou ; Hai Tang ; Jie Xu ; ^{xujie@mail.sysu.edu.cn} ; Kaihua Guo ; ^{guokh@mail.sysu.edu.cn}
• 关键词：amyloid β ; Aβ ; Alzheimer&rsquo ; s disease ; AD ; estrogen receptor α ; ERα ; formononetin ; Form ; soluble amyloid precursor protein α ; sAPPα
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：36-42
• 全文大小：2288 K
• 卷排序：639

文摘

To the best of our knowledge, this is the first report to demonstrate that Formononetin (Form) alleviated Aβ25-35-induced cytotoxicity in HT22 cells. Form promoted non-amyloidogenic cleavage of APP, which might be mediated through ERα-induced PI3K/Akt signaling. The protective effects of Form might be associated with the regulation of PI3K/Akt signaling and apoptosis-related proteins cleaved caspase-3 and Bcl-2.