Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
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- 作者：Slavka Hamulakovaa ; Patrik Popracb ; Klaudia Jomovac ; Vlasta Brezovab ; Peter Lauroc ; Lenka Drostinovac ; Daniel Jund ; Vendula Sepsovad ; Martina Hrabinovad ; Ondrej Soukupe ; Pavol Kristiana ; Zuzana Gazovaf ; g ; Zuzana Bednarikovaa ; f ; Kamil Kucae ; h ; Marian Valkob ; h ; marian.valko@stuba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Free copper ; Tacrine-coumarin hybrids ; Alzheimer's disease ; Oxidative stress ; DNA damage
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：52-62
- 全文大小：1126 K
文摘
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Tacrine-coumarin hybrids are agents against Cu(II)-induced oxidative stress in Alzheimer's disease.
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10">EPR spectroscopy was used to describe interaction between hybrids and Cu(II) ions.
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15">Coordinated hybrids to Cu(II) ions suppressed formation of HO
via Fenton reaction.- •
DNA damage protection study agrees with the results from EPR spin trapping study.
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Compound 5g showed the most potent acetylcholinesterase inhibitory activity.