Neuropathology and neurobehavioral alterations in a rat model of traumatic brain injury to occupants of vehicles targeted by underbody blasts

详细信息    查看全文

• 作者：Flaubert Tchantchou^a ; ^{ftchantchou@anes.umm.edu} ; William L. Fourney^b ; ^four@umd.edu ; Ulrich H. Leiste^b ; ^{uleiste@umd.edu} ; Joshua Vaughan^a ; ^{vaughan1009@gmail.com} ; Parisa Rangghran^a ; ^{prangghran@anes.umm.edu} ; Adam Puche^c ; ^{apuche@umaryland.edu} ; Gary Fiskum^a ; ^{gfiskum@anes.umm.edu}
• 关键词：Acceleration ; Apoptosis ; Inflammation ; Anxiety ; Synapse
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：289
• 期：Complete
• 页码：9-20
• 全文大小：1809 K
• 卷排序：289

文摘

Rat model of TBI specially relevant to occupants of vehicles targeted by land mines. Evidence of chronic anxiety-like behavior in rats after exposure to underbody blast. Presence of perivascular inflammation and hippocampal cell death 24 h post-blast. Evidence of BBB disruption and loss of synaptic proteins within 24 h post- blast.