Outcomes of infants with abdominal wall defects over 18 hsp>years

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• 作者：Juin Yee Kong^a ; ^b ; ^{kong.juin.yee@kkh.com.sg" class="auth_mail" title="E-mail the corresponding author} ; ^{juinyee@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Kee Thai Yeo^a ; ^b ; Mohamed E. Abdel-Latif^c ; ^d ; Barbara Bajuk^e ; Andrew J.A. Holland^f ; ^g ; Susan Adams^g ; ^h ; Ashish Jiwane^g ; ^h ; Sandra Heck^f ; Michael Yeong^a ; Kei Lui^a ; ^g ; Ju Lee Oei^a ; ^g ; on behalf of the New South Wales ; Australian Capital Territory Neonatal Intensive Care Units' Data Collection
• 关键词：AWD ; abdominal wall defect ; ACT ; Australian Capital Territory ; ART ; assisted reproductive technology ; BW ; birth weight ; CLD ; chronic lung disease ; OM ; omphalocele ; GS ; gastroschisis ; ICD-9 ; International Classification of Diseases Ninth Revision ; IUGR ; intrauterine growth restriction ; NEC ; necrotizing enterocolitis ; NICU ; neonatal intensive care unit ; NSW ; New South Wales ; ROM ; rupture of membranes ; SGA ; small for gestational age ; TPN ; total parenteral nutrition
• 刊名：Journal of Pediatric Surgery
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：51
• 期：10
• 页码：1644-1649
• 全文大小：276 K

文摘

Infants with abdominal wall defects (AWD) are at risk of poor outcomes including prolonged hospitalization, infections and mortality. Our objective was to describe and compare the outcomes of infants admitted with gastroschisis and omphalocele over 18 years.

<h4 id="absSec_2">Methodsh4>

Population-based study of clinical data and outcomes of live-born infants with AWD admitted to all tertiary-level neonatal intensive care units in New South Wales and Australian Capital Territory from 1992 to 2009.

<h4 id="absSec_3">Resulth4>

There were 502 infants with AWD &ndash; 336 gastroschisis, 166 omphalocele. Infants with gastroschisis required a longer duration of total parenteral nutrition (19 vs 4 days, p < 0.05), longer hospitalization (28 vs 15 days, p < 0.05) and had a higher rate of systemic infection [23.5% vs 13.3%, OR 1.77 (1.15&ndash;2.74), p < 0.05] compared to infants with omphalocele. Overall, omphalocele infants had higher mortality rate compared to gastroschisis infants [OR 2.77 (1.53, 5.04), p < 0.05]. Gastroschisis mortality rates increased from epoch 1 to epoch 3 (4.2% to 8.8%).

<h4 id="absSec_4">Conclusionh4>

Compared to infants with omphalocele, infants with gastroschisis required significantly longer hospitalization and parenteral nutrition with higher rates of infection. Infants with omphalocele had higher overall mortality rates. However, there has been an increase in the gastroschisis mortality rates but the cause for this is unclear.