Neural reflex pathway between cervical spinal and sympathetic ganglia in rabbits: implication for pathogenesis of cervical vertigo

详细信息    查看全文

• 作者：Jinliang Zuo ; MD^a ; ^{zjl.md@163.com" class="auth_mail} ; Jianlong Han ; MS^a ; Siqiang Qiu ; MS^a ; Fanghai Luan ; MS^a ; Xinwei Zhu ; MS^a ; Haoyuan Gao ; BS^a ; Anmin Chen ; PhD^b
• 关键词：Cervical spinal ganglion ; Cervical sympathetic ganglia ; FluoroGold ; Cervical vertigo ; Reflex arc ; Retrograde labeling
• 刊名：The Spine Journal
• 出版年：1 June 2014
• 年：2014
• 卷：14
• 期：6
• 页码：1005-1009
• 全文大小：744 K

文摘

A functional association between cervix and vertigo has been observed in patients with cervical vertigo, implicating correlation between cervical spinal and sympathetic ganglia. However, it is unclear where there is an anatomic connection between those two groups of ganglia.

Purpose

This study aimed to investigate the existence of the neural connections between cervical spinal and sympathetic ganglia.

Study design/setting

FluoroGold staining patterns in cervical spinal and sympathetic ganglia were evaluated using FluoroGold retrograde tracing in New Zealand rabbits.

Methods

New Zealand rabbits were randomly divided into superior cervical spinal ganglion injection groups, inferior cervical spinal ganglion injection groups, superior cervical sympathetic ganglion injection group, and inferior cervical sympathetic ganglion injection group. Four percent FluoroGold solution was injected into these ganglia. Distribution of FluoroGold in cervical spinal and sympathetic ganglia was observed under a microscope.

Results

When FluoroGold solution was injected into C2 and C3 superior cervical spinal ganglia or C5–C6 inferior cervical spinal ganglia, fluorescence was only observed in the ipsilateral superior or inferior cervical sympathetic ganglia, respectively. When FluoroGold solution was injected into superior or inferior cervical sympathetic ganglia, fluorescence was found mainly in the ipsilateral C3–C4 superior or C5–C8 inferior spinal ganglia. No fluorescence was observed in contralateral ganglia of experimental animals and all ganglia of matched control animals injected with physiological saline.

Conclusions

Bidirectional nerve fiber connections between cervical spinal and sympathetic ganglia were observed, and these connections are arranged in a segmental distribution. This observation may provide a possible neuroanatomic basis for the pathogenesis of cervical vertigo.