This study compared 4 testing protocols for detection of CPE from spiked stool specimens. Algorithms using Brilliance ESBL media significantly outperformed chromID CARBA algorithms. The difficulty detecting OXA-48-producers with the Carba NP test was a weakness of the testing. This shortcoming was partly overcome with the addition of chromID OXA-48 media to the algorithms. Selection of screening algorithms for CPE requires careful consideration of the local context.