Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
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- 作者：Wei Lia ; b ; 1 ; Xiaoqian Maa ; b ; 1 ; Na Lia ; b ; 1 ; Huasheng Liua ; b ; 1 ; Qiong Donga ; b ; Juan Zhanga ; b ; Cejun Yanga ; b ; Yin Liua ; b ; Qi Lianga ; b ; Shengwang Zhanga ; b ; Chang Xua ; b ; Wei Songc ; Shiming Tand ; Pengfei Ronga ; b ; Wei Wanga ; b ; weiw_bio@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Non-small cell lung cancer ; Resveratrol ; Hexokinases II ; Glycolysis ; Akt
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：349
- 期：2
- 页码：320-327
- 全文大小：1123 K
文摘
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Resveratrol decreased HK2 expression and impaired glucose metabolism in NSCLC cell lines.
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The inhibition of HK2 expression and glycolysis is mediated by Akt signaling pathway suppression.
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Resveratrol inhibited NSCLC in vitro and in vivo.