Lack of an association between obsessive-compulsive disorder and polymorphisms in the 3?untranslated region of GRIN2B in a Chinese Han population

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• 作者：Shiguo Liu^a ; ^b ; ^c ; Yingying Yin^d ; ^e ; Yanhui Liu^d ; ^e ; ^f ; Yuping Sun^a ; ^b ; ^c ; Xinhua Zhang^d ; ^e ; ¹ ; ^{xhzhang87@126.com} ; Xu Ma^g ; ^h ; ⁱ ; ^{genetic@263.net.cn}
• 关键词：OCD ; GRIN2B ; Polymorphism ; Association study
• 刊名：Psychiatry Research
• 出版年：2012
• 出版时间：30 March, 2012
• 年：2012
• 卷：196
• 期：1
• 页码：142-144
• 全文大小：142 K

文摘

Previous investigations have provided evidence that some polymorphisms in the 3?untranslated region (3'-UTR) of GRIN2B are associated with susceptibility to obsessive-compulsive disorder (OCD). We evaluated the genetic contribution of the rs1805502, rs1805476 and rs890 polymorphisms in the 3'-UTR of GRIN2B in 206 OCD patients and 413 controls in a Chinese Han population, and found no significant differences in genotypic and allelic frequencies between OCD cases and the controls. Our results suggest the lack of an association between OCD and polymorphisms in the 3'-UTR of GRIN2B in a Chinese Han population.