Silencing of Paralemmin-3 Protects Mice from lipopolysaccharide-induced acute lung injury
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- 作者：Shaoying Lia ; b ; 1 ; Liang Guoa ; 1 ; Yunfeng Zhaoc ; Pin Qiand ; Xuejun Lva ; Lanlan Qiana ; Qin wanga ; Guisheng Qiana ; Wei Yaoa ; weiyao.weiyao@live.cn" class="auth_mail" title="E-mail the corresponding author ; Xueling Wua ; e ; wuxueling76@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paralemmin-3 ; lipopolysaccharide ; Acute lung injury
- 刊名：Peptides
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：65-72
- 全文大小：2695 K
文摘
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In an LPS-induced acute lung injury mouse model, the expression of PALM3 was up-regulated in lung tissues.
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PALM3 expression in mouse lungs can be successfully silenced by lentivirus-mediated siRNA.
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Inhibiting PALM3 through the intratracheal application of specific siRNA protected against LPS-induced ALI.