New insights into the interaction of centrin with Sfi1
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- 作者：Juan Martinez-Sanz ; Liliane Assairi ; liliane.assairi@orange.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：HsCen1 to HsCen3 ; human centrin isoforms 1 to 3 ; Cdc31 ; yeast centrin ; Sfi1 ; Suppressor of fermentation-induced loss of stress resistance 1 ; XPC ; xeroderma pigmentosum complementation group C protein ; ITC ; isothermal titration calorimetry ; CD ; circular dichroism ; Tm ; midpoint denaturation temperature ; SP ; SwissPROT ; MTOC ; microtubule organizing centre ; R17 ; R18 are Sfi1 repeats
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1864
- 期：4
- 页码：319-330
- 全文大小：1534 K
文摘
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Centrin binds to Sfi1 containing 6 centrin-binding sites.
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Tryptophan is a major residue of the centrin-binding site.
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Calcium stabilizes the Sfi1–centrin complexes.
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Mutations in centrin-binding site affect the stability of the complexes.
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Centrin mutations affecting the cell cycle and the Sfi1–centrin complexes stability.
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