Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure-activity relationship models
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- 作者：Frank Hä ; mmerling frank.haemmerling@kit.edu ; Christopher Ladd Effio ; Sebastian Andris ; Jö ; rg Kittelmann ; Jü ; rgen Hubbuch ; juergen.hubbuch@kit.edu ;
- 关键词：Polyethylene glycol ; Precipitation ; Quantitative structure&ndash ; activity relationship (QSAR) ; Semi-mechanistic modeling ; Monoclonal antibody
- 刊名：Journal of Biotechnology
- 出版年：2017
- 出版时间：10 January 2017
- 年：2017
- 卷：241
- 期：Complete
- 页码：87-97
- 全文大小：2251 K
- 卷排序：241
文摘
A QSAR approach to predict protein precipitation by polyethylene glycol is presented. The generated QSAR models allow the prediction of precipitation curves for new proteins. Valuable insights about the properties influencing the precipitation behavior were gained. The methodology forwards computer-aided process design and process understanding following the tenet of QbD.