Prenatal growth characteristics of lymphatic malformations
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- 作者：William H. Peranteau ; peranteauw@email.chop.edu ; Suzanne D. Iyoob ; Matthew M. Boelig ; Nahla Khalek ; Julie S. Moldenhauer ; Mark P. Johnson ; Holly L. Hedrick ; Alan W. Flake ; Beverly G. Coleman ; N. Scott Adzick
- 关键词：Lymphatic malformation ; Fetus ; Sclerotherapy ; Prenatal diagnosis
- 刊名：Journal of Pediatric Surgery
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：52
- 期：1
- 页码：65-68
- 全文大小：521 K
- 卷排序：52
文摘
The natural history of prenatally diagnosed lymphatic malformations (LM) remains unknown. The ability to predict growth of a lesion is important to prenatal counseling and any future prenatal intervention. We describe the prenatal growth patterns of LMs as they relate to gestational age, anatomical location, and postnatal management.MethodsA retrospective review of fetuses prenatally diagnosed with an LM who were followed with serial ultrasounds from 2003 to 2014 was performed with attention to the growth of the lesion as indicated by the lesion volume ratio (LVR).ResultsThirty patients with LM had serial ultrasound measurements between 19 and 39 weeks gestation. The LVR increased in 53%, decreased in 23%, and remained stable in 23% of fetuses from the initial to the final ultrasound. Unlike other locations that demonstrated both positive and negative growth profiles, axillary lesions only demonstrated increased growth. Lesions with positive growth increased throughout gestation (peak LVR at 35 ± 3 weeks). Twenty-four patients had postnatal interventions, including surgical resection, sclerotherapy, and surgery + sclerotherapy.ConclusionLMs have variable prenatal growth profiles. The majority of lesions, especially axillary LMs, will continue to grow throughout gestation and will not reach a growth plateau until the end of gestation.Level of EvidenceLevel III (Retrospective cohort study).