From June 2010 to June 2013, a total of 487 patients without a history of CAD and HF were enrolled. All of the patients underwent plane multi-detector computed tomography. They were divided into four categories according to CAC scores: ≤10, 11–100, 101–400, and ≥401.
The proportion of patients with high NT-proBNP levels increased with CAC categories (p < 0.0001). The CAC score was associated with NT-proBNP levels ≥400 pg/ml, with an odds ratio of 2.901 (95% confidence interval: 1.368–6.151, p = 0.0055) for CAC scores ≥401 compared with CAC scores of 0–10 after adjustment for confounding factors. During the follow-up period of 497 ± 315 days, nine patients were admitted for HF. Kaplan–Meier analysis showed that patients with CAC scores ≥401 had a lower rate of freedom from admission for HF with cumulative incidences of 0.4%, 1%, 2%, and 8% for CAC scores of 0–10, 11–100, 101–400, and ≥401, respectively (p < 0.0001). Increasing CAC scores were associated with an increase in incidence of admission for HF, with a hazard ratio of 10.371 for CAC scores ≥401 (95% CI: 1.062–101.309, p = 0.0443) compared with CAC scores of 0–10 after adjustment for risk factors.
Severe CAC is an independent determinant of high NT-proBNP levels and a predictor of admission for HF in a population without a history of CAD or HF.
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