The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease

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• 作者：Vanessa Grubbs^a ; ^{vanessa.grubbs@ucsf.edu} ; Faviola Garcia^a ; ^{faviola.garcia@ucsf.edu} ; Bonnie L. Jue^b ; ^{bonnie.jue@ucsf.edu} ; Eric Vittinghoff^c ; ^{Eric.Vittinghoff@ucsf.edu} ; Mark Ryder^d ; ^{Mark.Ryder@ucsf.edu} ; David Lovett^e ; ^{David.Lovett@ucsf.edu} ; Jacqueline Carrillo^f ; ^{jacqueline.carrillo@ucsf.edu} ; Steven Offenbacher^g ; ^{steven_offenbacher@unc.edu} ; Peter Ganz^h ; ^{Peter.Ganz@ucsf.edu} ; Kirsten Bibbins-Domingoⁱ ; ^{Kirsten.bibbins-domingo@ucsf.edu} ; Neil R. Powe^j ; ^{neil.powe@ucsf.edu}
• 关键词：(max 6) chronic kidney disease ; Periodontal disease ; Non-surgical periodontal disease treatment ; Periodontitis ; oral health
• 刊名：Contemporary Clinical Trials
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：Complete
• 页码：143-150
• 全文大小：679 K
• 卷排序：53

文摘

Chronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects minorities and the poor, despite intense efforts targeting traditional risk factors. Periodontal diseases are common bacterial plaque-induced inflammatory conditions that can respond to treatment and have been implicated as a CKD risk factor. However there is limited evidence that treatment of periodontal disease slows the progression of CKD.Methods/designWe describe the protocol of the Kidney and Periodontal Disease (KAPD) study, a 12-month un-blinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: 1. immediate intensive non-surgical periodontal treatment or 2. rescue treatment with delayed intensive treatment. The goals of this pilot study are to test the feasibility of conducting a larger trial in an ethnically and racially diverse, underserved population (mostly poor and/or low literacy) with both CKD and significant periodontal disease to determine the effect of intensive periodontal treatment on renal and inflammatory biomarkers over a 12-month period.ResultsTo date, KAPD has identified 634 potentially eligible patients who were invited to in-person screening. Of the 83 (13.1%) of potentially eligible patients who attended in-person screening, 51 (61.4%) were eligible for participation and 46 enrolled in the study. The mean age of participants is 59.2 years (range 34 to 73). Twenty of the participants (43.5%) are Black and 22 (47.8%) are Hispanic.DiscussionResults from the KAPD study will provide needed preliminary evidence of the effectiveness of non-surgical periodontal treatment to slow CKD progression and inform the design future clinical research trials.