Comparison between amine-terminated phthalocyanines and their chlorambucil conjugates: Synthesis, spectroscopic properties, and in vitro anticancer activity

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• 作者：Xiao-Hui Peng ; Shao-Fang Chen ; Bi-Yuan Zheng ; Bing-De Zheng ; Qiao-Feng Zheng ; Xing-Shu Li ; Mei-Rong Ke ; Jian-Dong Huang ; ^{jdhuang@fzu.edu.cn} ; ^{13805009843@163.com}
• 关键词：Photodynamic therapy ; Phthalocyanine ; Chlorambucil ; Structure-activity relationship ; Anticancer
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：73
• 期：4
• 页码：378-384
• 全文大小：808 K
• 卷排序：73

文摘

Two novel phthalocyanine-CLB conjugates (5 and 7) have been synthetized. The structure-activity relationships of these compounds have been discussed. 6 and 7 show weaker singlet oxygen generation efficiency than that of 4 and 5. Compound 6 shows the highest photocytotoxicity against HepG2 cells (IC50 = 9 nM).