Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives
详细信息 查看全文
- 作者：Zi-Long Songa ; 1 ; Mei-Juan Wanga ; 1 ; Lanlan Lia ; Dan Wua ; Yu-Han Wangc ; Li-Ting Yana ; Susan L. Morris-Natschkeb ; Ying-Qian Liua ; yqliu@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yong-Long Zhaoa ; Chih-Ya Wangb ; Huanxiang Liua ; hxliu@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Masuo Gotob ; Heng Liue ; Gao-Xiang Zhub ; Kuo-Hsiung Leeb ; d ; khlee@email.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Camptothecin ; Cytotoxic activity ; Molecular docking ; Sulfonylamidine ; Synthesis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：109-120
- 全文大小：1693 K
文摘
- •
20(S)-Sulfonylamidine CPT-derivatives were prepared and tested for cytotoxicity.
- •
Several analogs showed superior cytotoxic activity compared to irinotecan.
- •
Key structural features related to cytotoxicity were identified by SAR analysis.
- •
Compounds
- •
These compounds are new generation CPT-derived antitumor agents.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |