Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression

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• 作者：Quanfang Huang^a ; Facheng Bai^b ; Jinlan Nie^b ; Shengjuan Lu^b ; Chunyuang Lu^b ; Xunshuai Zhu^b ; Lang Zhuo^c ; Xing Lin^b ; ^{gxLx60@163.com}
• 关键词：Didymin ; MAPK pathway ; NF-κB pathway ; RKIP
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：130-138
• 全文大小：1723 K
• 卷排序：42

文摘

Didymin alleviates CCl4-induced liver injury. Didymin has strongly anti-inflammatory effect. Didymin inhibits the MAPK and NF-κB pathways. Didymin promotes RKIP expression. The protective effects of didymin are largely abolished by locostatin.