Decreased responsiveness following lithium discontinuation in bipolar disorder: A naturalistic observation study
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- 作者：Sibel Cakira ; drsibelcakir@yahoo.com ; Olcay Yazıcıa ; Robert M. Postb
- 关键词：Bipolar disorders ; Lithium ; Discontinuation ; Long term treatment ; Unresponsiviness ; Response ; Treatment resistance
- 刊名：Psychiatry Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：247
- 期：Complete
- 页码：305-309
- 全文大小：269 K
- 卷排序：247
文摘
The attenuated response or unresponsiveness was seen in more than a quarter of patients with bipolar disorder following the discontinuation. The attenuated response was found as many as unresponsiveness in reinstitution of lithium. The acquired unresponsiveness was more often in partially responders than in excellent responders. Those who had episode recurrences during the discontinuation were more likely to show reduced responsiveness. Duration of discontinuation seems to be longer in patients who would have unresponsiveness.