Identification of drug resistance and immune-driven variations in hepatitis C virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward personalized medicine

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• 作者：Aqsa Ikram^a ; Ayesha Obaid^a ; Faryal Mehwish Awan^a ; Rumeza Hanif^b ; Anam Naz^a ; Rehan Zafar Paracha^c ; Amjad Ali^a ; Hussnain Ahmed Janjua^a ; ^{janjua.hussnain@gmail.com} ; ^{hussnain.janjua@asab.nust.edu.pk}
• 关键词：Direct acting antiviral drugs ; Drug resistance mutations ; Epitope mutations ; Overlap
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：112-124
• 全文大小：4150 K
• 卷排序：137

文摘

Reported drug resistance mutations within NS3/4A, NS5A and NS5B regions is explored. Prevalence of these mutations among all major HCV genotypes is investigated. Potential overlap between drug resistance and immune driven mutations are reported. Knowledge of host HLA type/HCV genotype is important to optimize personalized therapy.