The olfactory bulbectomized rat as a model of depression: The hippocampal pathway
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- 作者：J.C. Morales-Medinaa ; jmoralesm@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author ; jcmm.cinvestav@gmail.com" class="auth_mail" title="E-mail the corresponding author ; T. Iannittib ; tommaso.iannitti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; A. Freemanc ; afreem16@kent.edu" class="auth_mail" title="E-mail the corresponding author ; H.K. Caldwellc ; d ; hcaldwel@kent.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AChE ; acetylcholinesterase ; BDNF ; brain derived neurotrophic factor ; CaMKII ; calmodulin-dependent protein kinase II ; DG ; dentate gyrus ; DHEA ; dehydroepiandrosterone ; EC ; entorhinal cortex ; FST ; forced swim test ; GSK-3β ; glycogen synthase kinase 3β ; LTP ; long-term potentiation ; MWM ; Morris water maze ; NMDA ; N-Methyl-d-aspartate ; NORT ; novel object recognition test ; NPY ; neuropeptide Y ; p-CREB ; cAMP response element-binding protein phosphorylation ; p-ERK1 ; extra-cellular signal-regulated kinase 1
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：562-575
- 全文大小：2135 K
文摘
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Olfactory bulbectomy is a model of major cellular dysfunction in the hippocampus.
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Olfactory bulbectomy (OBX) induces behavioral deficits similar to clinical depression.
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Imipramine and curcumin reduce hippocampal neuroinflammation in OBX rats.
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Citalopram and ZSET1446 improve dentate gyrus neurogenesis in OBX rats.
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Nefiracetam, sunifiram and rivastigmine restore LTP in CA1 hippocampus in OBX rats.