Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties
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- 作者：Heather Kanga ; Pojeong Parkb ; Zuner A. Bortolottob ; Simon D. Brandtc ; Tristan Colestockd ; Jason Wallachd ; Graham L. Collingridgeb ; e ; f ; David Lodgeb ; David.Lodge@Bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ephenidine ; Ketamine ; NMDA receptor ; Dissociative hallucinogen ; Legal high ; MK-801 binding ; Outward rectification ; Long-term potentiation
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：144-149
- 全文大小：1356 K
文摘
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New ‘legal high’, the dissociative ephenidine, displaces MK-801 binding.
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Ephenidine, like ketamine, blocks NMDA receptor mediated synaptic potentials and plasticity.
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Ephenidine, like ketamine, blocks the NMDA receptor in a highly voltage-dependent manner.
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Ephenidine blocks long-term potentiation, LTP.
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NMDA receptor antagonism likely underlies the psychoactive effects of ephenidine.
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