Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials

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• 作者：Fang Fang^a ; Ke Ni^b ; Yiting Cai^a ; Jin Shang^a ; Xiaoke Zhang^a ; Chengliang Xiong^a ; ^c ; ^{clxiong951@sina.com}
• 关键词：PCOS ; Vitamin D ; RCTs ; Meta-analysis
• 刊名：Complementary Therapies in Clinical Practice
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：Complete
• 页码：53-60
• 全文大小：1588 K
• 卷排序：26

文摘

To evaluate the effect of vitamin D supplementation on patients with PCOS.MethodsWe performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients.Main resultsNine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39).ConclusionsEvidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS.