CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway
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- 作者：Zhipeng Tanga ; 1 ; Wendan Yua ; 1 ; Changlin Zhangb ; 1 ; Shilei Zhaoa ; Zhenlong Yua ; Xiangsheng Xiaob ; Ranran Tanga ; Yang Xuana ; Wenjing Yanga ; Jiaojiao Haoa ; Tingting Xua ; Qianyi Zhanga ; Wenlin Huangb ; c ; Wuguo Dengb ; c ; dengwg@sysucc.org.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Guoa ; wei1015@msn.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CBP ; CPSF4 ; hTERT ; Lung cancer
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：10
- 期：2
- 页码：317-329
- 全文大小：3544 K
文摘
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Knockdown of CBP or inhibition of its HAT activity inhibits lung cancer cell growth and induces apoptosis.
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Knockdown of CBP or inhibition of its HAT activity inactivates MAPK signaling pathway.
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CBP interacts with and acetylates CPSF4 to promote hTERT expression and tumor growth in lung cancer cells.
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Overexpression of both CBP and CPSF4 predicted poor prognosis of the patients with lung adenocarcinomas.