Hyperbaric oxygen treatment reverses radiation induced pro-fibrotic and oxidative stress responses in a rat model

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• 作者：N. Oscarsson^a ; ^{nicklas.oscarsson@vgregion.se} ; ^{Nicklas.oscarsson@gmail.com} ; L. Ny^b ; J. Mö ; lne^c ; F. Lind^d ; S.-E. Ricksten^a ; H. Seeman-Lodding^a ; D. Giglio^b ; ^e
• 关键词：8-OHdG ; 8-hydroxy-2&prime ; -deoxyguanosine ; HBOT ; Hyperbaric Oxygen Therapy ; HO-1 ; Heme oxygenase 1 ; IFN-γ ; Interferon gamma ; IL-x ; Interleukin ; qPCR ; quantitative Polymerase Chain Reaction ; ROS ; Reactive Oxygen Species ; RT ; Radiotherapy ; SOD-x ; Superoxid dismutase ; TGF-β ; Transforming growth factor beta ; TNF-α ; Tumor necrosis factor
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：248-255
• 全文大小：1432 K
• 卷排序：103

文摘

Bladder irradiation induces an oxidative stress reaction. The oxidative stress initiates an inflammatory and pro-fibrotic response. Hyperbaric oxygen may reverse oxidative stress induced by radiation. Hyperbaric oxygen alone did not induce any changes in the factors studied.