Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats
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- 作者：Deqing Xiong1 ; Yuanyuan Deng1 ; Bin Huang ; Caixia Yin ; Bo Liu ; Jingshan Shi ; Qihai Gong ; gqh@zmc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Icariin ; Cerebral ischemia ; Inflammation ; Peroxisome proliferator-activated receptor ; Nuclear factor κB
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：157-162
- 全文大小：678 K
文摘
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Icariin has neuroprotective effect on ischemic stroke in rat.
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Icariin inhibits inflammatory responses in ischemic stroke.
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Icariin suppresses IκB degradation and NF-κB activation in ischemic stroke.
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Icariin up-regulates both PPARα and PPARγ protein levels in ischemic stroke.