Fifteen compounds of novel 1H-pyrazolo [3,4-b]pyridine derivatives were designed and synthesized.
Molecular docking was carried out against DNA.
In vitro anti-proliferative activity against HePG-2, MCF-7, HCT-116, and PC-3 cell lines, DNA binding affinity and association constants assay were carried out.
A strong relationship exists between the anticancer activity and the DNA binding activity.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址:北京市海淀区学院路29号 邮编:100083 电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700 |