Establish Albumin-creatinine Ratio Reference Value of Adults in the Rural Area of Hebei Province

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• 作者：Qiao-jing Liang^a ; ^&dagger ; ; Wen Huang^a ; ^&dagger ; ; ^{25911412@163.com" class="auth_mail" title="E-mail the corresponding author} ; Guo-juan Zhang^a ; Ning-li Wang^b ; ^{wningli@vip.163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：albumin-creatinine ratio ; albuminuria ; chronic kidney disease
• 刊名：Chinese Medical Sciences Journal
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：31
• 期：1
• 页码：23-30

文摘

To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province.

Methods

This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate (eGFR) < 60 ml/(min·1.73 m²), apparently healthy subjects (1168) were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe's kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit.

Results

The normal upper limit of ACR was 28.71 mg/g (3.25 mg/mmol) for males and 31.85 mg/g (3.60 mg/mmol) for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%.

Conclusion

The ACR reference value in the rural of Hebei province is higher than that of the Western population.