Polymer hydrogel particles as biocompatible AFM probes to study CD44/hyaluronic acid interactions on cells
详细信息 查看全文
- 作者：Steve Martina ; Hanqing Wangb ; Tino Rathkea ; Ulf Andereggc ; Stephanie Mö ; llerd ; Matthias Schnabelrauchd ; Tilo Pompea ; Stephan Schmidta ; b ; stephan.schmidt@hhu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cell adhesion ; Adhesion force ; PEG ; Biomimetic ; Hyaluronan ; Colloidal probe ; Contact phenomena
- 刊名：Polymer
- 出版年：2016
- 出版时间：12 October 2016
- 年：2016
- 卷：102
- 期：Complete
- 页码：342-349
- 全文大小：1312 K
文摘
- •
Use of soft hyaluronic acid AFM probes as chemical and mechanical cell ECM mimic.
- •
CD44 receptor presenting cells specifically interact with hyaluronic acid probes.
- •
Cells lacking CD44 showed significantly reduced interaction forces.
- •
CD44/hyaluronic acid interactions level off after about 30 s of contact.