Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

详细信息    查看全文

• 作者：Lauren Macklin^a ; ^c ; Chelsea M. Griffith^a ; ^c ; Yan Cai^a ; ^c ; ^d ; Gregory M. Rose^a ; ^b ; ^c ; Xiao-Xin Yan^b ; ^c ; ^d ; Peter R. Patrylo^a ; ^b ; ^c ; ^{ppatrylo@siumed.edu}
• 关键词：Aβ ; beta-amyloid ; AD ; Alzheimer's disease ; APP ; amyloid precursor protein ; AUC ; area under curve ; hAPP ; human amyloid precursor protein ; ip ; intraperitoneal ; ipGTT ; intraperitoneal glucose tolerance test ; ipITT ; intraperitoneal insulin tolerance test ; PS1 ; presenilin 1 ; RM ANOVA ; repeated measures ANOVA ; WT ; wild-type
• 刊名：Experimental Gerontology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：9-18
• 全文大小：1379 K
• 卷排序：88

文摘

The APP/PS1 mouse is an animal model of Alzheimer's disease. Aβ plaques are seen at 6–7 months in APP/PS1 mice but not at 2 months. Spatial learning and memory is impaired in APP/PS1 mice at 8–9 months. In contrast, peripheral glucose regulation is altered by 2 months in APP/PS1 mice. Thus, a pre-diabetic phenotype precedes classical AD-related pathology.