A secretome analysis reveals that PPARα is upregulated by fractionated-dose γ-irradiation in three-dimensional keratinocyte cultures
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- 作者：Jeeyong Lee ; Hyun-Ji Kim ; Jae Youn Yi ; yjy_71@kcch.re.kr
- 关键词：Keratinocyte ; γ-irradiation ; Three-dimensional culture ; Microarray ; Secretome ; PPARα
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2017
- 出版时间：8 January 2017
- 年：2017
- 卷：482
- 期：2
- 页码：270-276
- 全文大小：1051 K
- 卷排序：482
文摘
γ-irradiation induced changes of cell adhesion, angiogenesis, and immune system in secretome of 3D-cultured keratinocytes. Peroxisome proliferator-activated receptor-α (PPARα) was upregulated in response to fractionated-dose γ-irradiation. The known PPARα target genes were differentially regulated by fractionated-dose γ-irradiation.