2-(2-Phenylethyl)chromones from Chinese eaglewood

详细信息    查看全文

• 作者：Lin Yang^a ; ^b ; ^c ; Lirui Qiao^b ; Dan Xie^b ; Yuhe Yuan^b ; Naihong Chen^b ; Jungui Dai^b ; ^{jgdai@imm.ac.cn} ; Shunxing Guo^a ; ^{sxguo2006@yahoo.com.cn}
• 关键词：Aquilaria sinensis ; Thymelaeaceae ; Chinese eaglewood ; 2-(2-Phenylethyl)chromone ; 2-(2-Phenylethenyl)chromone ; Neuroprotective activity
• 刊名：Phytochemistry
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：76
• 期：Complete
• 页码：92-97
• 全文大小：282 K

文摘

2-(2-Phenylethyl) chromones and a 2-(2-phenylethenyl) chromone, were isolated from the ethanolic extract of Chinese eaglewood. Their structures were determined on the basis of extensive analyses of spectroscopic data. Among those, one showed significant neuroprotective activities against both glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells at a concentration of 10 ¦ÌM and increased cell viability by 82.2 % and 86.9 % , respectively.