Avidity of human T cell receptor engineered CD4+ T cells drives T-helper differentiation fate
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- 作者：Patrick Adaira ; b ; ; Yong Chan Kima ; Kathleen P. Pratta ; David W. Scotta
- 关键词：APC ; antigen presenting cells ; HLA ; human leukocyte antigen ; IL ; interleukin ; IMGT ; international immunogenetics ; MHC ; major histocompatibility complex ; PBMCs ; peripheral blood mononuclear cells ; pC2 ; FVIII C2 domain peptide 2191-2210 ; TCR ; T cell receptor
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：299
- 期：Complete
- 页码：30-41
- 全文大小：2107 K
文摘
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Human TCR engineered cells can be T-helper differentiated despite retroviral transduction.
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TCR avidity for cognate antigen dictates the yield of Th1/Th2 hybrid TCR engineered cells.
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T-helper differentiated engineered cells maintain phenotype based on TCR avidity.
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TCR avidity can accelerate Th1 differentiation of TCR engineered cells.
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