Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells

详细信息    查看全文

• 作者：Zhiquan Chen^a ; ¹ ; Xi Xie^b ; ^c ; ¹ ; ^{xiaprilxie@berkeley.edu} ; ^{xiexi@hainu.edu.cn} ; Junying Huang^a ; Wenyan Gong^a ; Xiaoyu Zhu^c ; Qiuhong Chen^a ; Jiani Huang^a ; Heqing Huang^a ; ^{huangheq@mail.sysu.edu.cn}
• 关键词：AGEs ; advanced glycation end products ; ARE ; anti-oxidant response element ; Cx43 ; connexin43 ; DN ; diabetic nephropathy ; ECM ; extracellular matrix ; EMSA ; electrophoretic mobility shift assay ; FN ; fibronectin ; GMCs ; glomerular messangial cells ; GJIC ; Gap junctional intercellular communication ; HO-1 ; heme oxygenase 1 ; ICAM-1 ; intercellular adhesion molecule-1 ; Keap1 ; kelch like ECH associated protein 1 ; MAPK ; mitogen-activated protein kinase ; Nrf2 ; nuclear factor E2-related factor 2 ; PKC ; protein ki
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：77-86
• 全文大小：1391 K
• 卷排序：102

文摘

Cx43 overexpression reduced ROS generation by boost Nrf2/ARE signaling under high glucose condition. Inhibition of c-Src activity promoted nucleus accumulation of Nrf2. Over-expressed Cx43 inhibited c-Src activity and the interaction between c-Src and Nrf2 in GMCs cultured in high glucose.